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The clinical significance of biased dual GIPRAs and GLP-1RAs has not yet been assessed due to the limited existence of such clinically available drugs

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Applying the patch for longer periods can lead to side effects such as: Erythema (redness) Pruritus (itching) Contact dermatitis Skin inflammation Burning sensation GLP-1 transdermal patches may also cause hypersensitivity reactions and skin sensitization after repeated exposure

[PubMed: 27402097] (Description of an online compendium of cases of liver toxicity attributed to HDS products, lists at least 46 published cases of green tea associated liver injury and concludes that green tea may warrant a warning label)